| 2021-Louisville (ACC) |
| Sep. 6 | vs | Mississippi (10-3) | L | 24 | 43 | at Atlanta, GA |
| Sep. 11 | vs | Eastern Kentucky ( ) | W | 30 | 3 |
| Sep. 17 | vs | Central Florida (9-4) | W | 42 | 35 |
| Sep. 25 | at | *Florida State (5-7) | W | 31 | 23 |
| Oct. 2 | at | *Wake Forest (11-3) | L | 34 | 37 |
| Oct. 9 | vs | *Virginia (6-6) | L | 33 | 34 |
| Oct. 23 | vs | *Boston College (6-6) | W | 28 | 14 |
| Oct. 30 | at | *North Carolina State (9-3) | L | 13 | 28 |
| Nov. 6 | vs | *Clemson (10-3) | L | 24 | 30 |
| Nov. 13 | vs | *Syracuse (5-7) | W | 41 | 3 |
| Nov. 18 | at | *Duke (3-9) | W | 62 | 22 |
| Nov. 27 | vs | Kentucky (10-3) | L | 21 | 52 |
| Dec. 28 | vs | Air Force (10-3) | L | 28 | 31 | at Dallas, TX | First Responder Bowl |
| | 6-7-0 | | 411 | 355 |
| 2020-Louisville (ACC) |
| Sep. 12 | vs | Western Kentucky (5-7) | W | 35 | 21 |
| Sep. 19 | vs | *Miami (Florida) (8-3) | L | 34 | 47 |
| Sep. 26 | at | *Pittsburgh (6-5) | L | 20 | 23 |
| Oct. 9 | at | *Georgia Tech (3-7) | L | 27 | 46 |
| Oct. 17 | at | *Notre Dame (10-2) | L | 7 | 12 |
| Oct. 24 | vs | *Florida State (3-6) | W | 48 | 16 |
| Oct. 31 | vs | *Virginia Tech (5-6) | L | 35 | 42 |
| Nov. 14 | at | *Virginia (5-5) | L | 17 | 31 |
| Nov. 20 | vs | *Syracuse (1-10) | W | 30 | 0 |
| Nov. 28 | at | *Boston College (6-5) | L | 27 | 34 |
| Dec. 12 | vs | *Wake Forest (4-5) | W | 45 | 21 |
| | 4-7-0 | | 325 | 293 |
| 2019-Louisville (ACC) |
| Sep. 2 | vs | Notre Dame (11-2) | L | 17 | 35 |
| Sep. 7 | vs | Eastern Kentucky ( ) | W | 42 | 0 |
| Sep. 14 | vs | Western Kentucky (9-4) | W | 38 | 21 | at Nashville, TN |
| Sep. 21 | at | *Florida State (6-7) | L | 24 | 35 |
| Oct. 5 | vs | *Boston College (6-7) | W | 41 | 39 |
| Oct. 12 | at | *Wake Forest (8-5) | W | 62 | 59 |
| Oct. 19 | vs | *Clemson (14-1) | L | 10 | 45 |
| Oct. 26 | vs | *Virginia (9-5) | W | 28 | 21 |
| Nov. 9 | at | *Miami (Florida) (6-7) | L | 27 | 52 |
| Nov. 16 | at | *North Carolina State (4-8) | W | 34 | 20 |
| Nov. 23 | vs | *Syracuse (5-7) | W | 56 | 34 |
| Nov. 30 | at | Kentucky (8-5) | L | 13 | 45 |
| Dec. 30 | vs | Mississippi State (6-7) | W | 38 | 28 | at Nashville, TN | Music City Bowl |
| | 8-5-0 | | 430 | 434 |
| 2018-Louisville (ACC) |
| Sep. 1 | vs | Alabama (14-1) | L | 14 | 51 | at Orlando, FL |
| Sep. 8 | vs | Indiana State ( ) | W | 31 | 7 |
| Sep. 15 | vs | Western Kentucky (3-9) | W | 20 | 17 |
| Sep. 22 | at | *Virginia (8-5) | L | 3 | 27 |
| Sep. 29 | vs | *Florida State (5-7) | L | 24 | 28 |
| Oct. 5 | vs | *Georgia Tech (7-6) | L | 31 | 66 |
| Oct. 13 | at | *Boston College (7-5) | L | 20 | 38 |
| Oct. 27 | vs | *Wake Forest (7-6) | L | 35 | 56 |
| Nov. 3 | at | *Clemson (15-0) | L | 16 | 77 |
| Nov. 9 | at | *Syracuse (10-3) | L | 23 | 54 |
| Nov. 17 | vs | *North Carolina State (9-4) | L | 10 | 52 |
| Nov. 24 | vs | Kentucky (10-3) | L | 10 | 56 |
| | 2-10-0 | | 237 | 529 |
| 2017-Louisville (ACC) |
| Sep. 2 | vs | Purdue (7-6) | W | 35 | 28 | at Indianapolis, IN |
| Sep. 9 | at | *North Carolina (3-9) | W | 47 | 35 |
| Sep. 16 | vs | *Clemson (12-2) | L | 21 | 47 |
| Sep. 23 | vs | Kent State (2-10) | W | 42 | 3 |
| Sep. 30 | vs | Murray State ( ) | W | 55 | 10 |
| Oct. 5 | at | *North Carolina State (9-4) | L | 25 | 39 |
| Oct. 14 | vs | *Boston College (7-6) | L | 42 | 45 |
| Oct. 21 | at | *Florida State (7-6) | W | 31 | 28 |
| Oct. 28 | at | *Wake Forest (8-5) | L | 32 | 42 |
| Nov. 11 | vs | *Virginia (6-7) | W | 38 | 21 |
| Nov. 18 | vs | *Syracuse (4-8) | W | 56 | 10 |
| Nov. 25 | at | Kentucky (7-6) | W | 44 | 17 |
| Dec. 30 | vs | Mississippi State (9-4) | L | 27 | 31 | at Jacksonville, FL | TaxSlayer Bowl |
| | 8-5-0 | | 495 | 356 |
| 2016-Louisville (ACC) |
| Sep. 1 | vs | Charlotte (4-8) | W | 70 | 14 |
| Sep. 9 | at | *Syracuse (4-8) | W | 62 | 28 |
| Sep. 17 | vs | *Florida State (10-3) | W | 63 | 20 |
| Sep. 24 | at | Marshall (3-9) | W | 59 | 28 |
| Oct. 1 | at | *Clemson (14-1) | L | 36 | 42 |
| Oct. 14 | vs | *Duke (4-8) | W | 24 | 14 |
| Oct. 22 | vs | *North Carolina State (7-6) | W | 54 | 13 |
| Oct. 29 | at | *Virginia (2-10) | W | 32 | 25 |
| Nov. 5 | at | *Boston College (7-6) | W | 52 | 7 |
| Nov. 12 | vs | *Wake Forest (7-6) | W | 44 | 12 |
| Nov. 17 | at | Houston (9-4) | L | 10 | 36 |
| Nov. 26 | vs | Kentucky (7-6) | L | 38 | 41 |
| Dec. 31 | vs | Louisiana State (8-4) | L | 9 | 29 | at Orlando, FL | Citrus Bowl |
| | 9-4-0 | | 553 | 309 |
| 2015-Louisville (ACC) |
| Sep. 5 | vs | Auburn (7-6) | L | 24 | 31 | at Atlanta, GA |
| Sep. 12 | vs | Houston (13-1) | L | 31 | 34 |
| Sep. 17 | vs | *Clemson (14-1) | L | 17 | 20 |
| Sep. 26 | vs | Samford ( ) | W | 45 | 3 |
| Oct. 3 | at | *North Carolina State (7-6) | W | 20 | 13 |
| Oct. 17 | at | *Florida State (10-3) | L | 21 | 41 |
| Oct. 24 | vs | *Boston College (3-9) | W | 17 | 14 |
| Oct. 30 | at | *Wake Forest (3-9) | W | 20 | 19 |
| Nov. 7 | vs | *Syracuse (4-8) | W | 41 | 17 |
| Nov. 14 | vs | *Virginia (4-8) | W | 38 | 31 |
| Nov. 21 | at | *Pittsburgh (8-5) | L | 34 | 45 |
| Nov. 28 | at | Kentucky (5-7) | W | 38 | 24 |
| Dec. 30 | vs | Texas A&M (8-5) | W | 27 | 21 | at Nashville, TN | Music City Bowl |
| | 8-5-0 | | 373 | 313 |
| 2014-Louisville (ACC) |
| Sep. 1 | vs | *Miami (Florida) (6-7) | W | 31 | 13 |
| Sep. 6 | vs | Murray State ( ) | W | 66 | 21 |
| Sep. 13 | at | *Virginia (5-7) | L | 21 | 23 |
| Sep. 20 | at | Florida International (4-8) | W | 34 | 3 |
| Sep. 27 | vs | *Wake Forest (3-9) | W | 20 | 10 |
| Oct. 3 | at | *Syracuse (3-9) | W | 28 | 6 |
| Oct. 11 | at | *Clemson (10-3) | L | 17 | 23 |
| Oct. 18 | vs | *North Carolina State (8-5) | W | 30 | 18 |
| Oct. 30 | vs | *Florida State (13-1) | L | 31 | 42 |
| Nov. 8 | at | *Boston College (7-6) | W | 38 | 19 |
| Nov. 22 | at | Notre Dame (8-5) | W | 31 | 28 |
| Nov. 29 | vs | Kentucky (5-7) | W | 44 | 40 |
| Dec. 30 | vs | Georgia (10-3) | L | 14 | 37 | at Charlotte, NC | Belk Bowl |
| | 9-4-0 | | 405 | 283 |
| 2013-Louisville (American) |
| Sep. 1 | vs | Ohio (7-6) | W | 49 | 7 |
| Sep. 7 | vs | Eastern Kentucky ( ) | W | 44 | 7 |
| Sep. 14 | at | Kentucky (2-10) | W | 27 | 13 |
| Sep. 21 | vs | Florida International (1-11) | W | 72 | 0 |
| Oct. 5 | at | *Temple (2-10) | W | 30 | 7 |
| Oct. 10 | vs | *Rutgers (6-7) | W | 24 | 10 |
| Oct. 18 | vs | *Central Florida (12-1) | L | 35 | 38 |
| Oct. 26 | at | *South Florida (2-10) | W | 34 | 3 |
| Nov. 8 | at | *Connecticut (3-9) | W | 31 | 10 |
| Nov. 16 | vs | *Houston (8-5) | W | 20 | 13 |
| Nov. 23 | vs | *Memphis (3-9) | W | 24 | 17 |
| Dec. 5 | at | *Cincinnati (9-4) | W | 31 | 24 |
| Dec. 28 | vs | Miami (Florida) (9-4) | W | 36 | 9 | at Orlando, FL | Russell Athletic Bowl |
| | 12-1-0 | | 457 | 158 |
| 2012-Louisville (Big East) |
| Sep. 2 | vs | Kentucky (2-10) | W | 32 | 14 |
| Sep. 8 | vs | Missouri State ( ) | W | 35 | 7 |
| Sep. 15 | vs | North Carolina (8-4) | W | 39 | 34 |
| Sep. 22 | at | Florida International (3-9) | W | 28 | 21 |
| Sep. 29 | at | Southern Mississippi (0-12) | W | 21 | 17 |
| Oct. 13 | at | *Pittsburgh (6-7) | W | 45 | 35 |
| Oct. 20 | vs | *South Florida (3-9) | W | 27 | 25 |
| Oct. 26 | vs | *Cincinnati (10-3) | W | 34 | 31 |
| Nov. 3 | vs | *Temple (4-7) | W | 45 | 17 |
| Nov. 10 | at | *Syracuse (8-5) | L | 26 | 45 |
| Nov. 24 | vs | *Connecticut (5-7) | L | 20 | 23 |
| Nov. 29 | at | *Rutgers (9-4) | W | 20 | 17 |
| Jan. 2 | vs | Florida (11-2) | W | 33 | 23 | at New Orleans, LA | Sugar Bowl |
| | 11-2-0 | | 405 | 309 |
| 2011-Louisville (Big East) |
| Sep. 1 | vs | Murray State ( ) | W | 21 | 9 |
| Sep. 9 | vs | Florida International (8-5) | L | 17 | 24 |
| Sep. 17 | at | Kentucky (5-7) | W | 24 | 17 |
| Oct. 1 | vs | Marshall (7-6) | L | 13 | 17 |
| Oct. 8 | at | North Carolina (7-6) | L | 7 | 14 |
| Oct. 15 | at | *Cincinnati (10-3) | L | 16 | 25 |
| Oct. 21 | vs | *Rutgers (9-4) | W | 16 | 14 |
| Oct. 29 | vs | *Syracuse (5-7) | W | 27 | 10 |
| Nov. 5 | at | *West Virginia (10-3) | W | 38 | 35 |
| Nov. 12 | vs | *Pittsburgh (6-7) | L | 14 | 21 |
| Nov. 19 | at | *Connecticut (5-7) | W | 34 | 20 |
| Nov. 25 | at | *South Florida (5-7) | W | 34 | 24 |
| Dec. 27 | vs | North Carolina State (8-5) | L | 24 | 31 | at Charlotte, NC | Belk Bowl |
| | 7-6-0 | | 285 | 261 |
| 2010-Louisville (Big East) |
| Sep. 4 | vs | Kentucky (6-7) | L | 16 | 23 |
| Sep. 11 | vs | Eastern Kentucky ( ) | W | 23 | 13 |
| Sep. 18 | at | Oregon State (5-7) | L | 28 | 35 |
| Oct. 2 | at | Arkansas State (4-8) | W | 34 | 24 |
| Oct. 9 | vs | Memphis (1-11) | W | 56 | 0 |
| Oct. 15 | vs | *Cincinnati (4-8) | L | 27 | 35 |
| Oct. 23 | vs | *Connecticut (8-5) | W | 26 | 0 |
| Oct. 30 | at | *Pittsburgh (8-5) | L | 3 | 20 |
| Nov. 6 | at | *Syracuse (8-5) | W | 28 | 20 |
| Nov. 13 | vs | *South Florida (8-5) | L | 21 | 24 |
| Nov. 20 | vs | *West Virginia (9-4) | L | 10 | 17 |
| Nov. 26 | at | *Rutgers (4-8) | W | 40 | 13 |
| Dec. 21 | vs | Southern Mississippi (8-5) | W | 31 | 28 | at St. Petersburg, FL | Beef O'Brady's Bowl |
| | 7-6-0 | | 343 | 252 |
| 2009-Louisville (Big East) |
| Sep. 5 | vs | Indiana State ( ) | W | 30 | 10 |
| Sep. 19 | at | Kentucky (7-6) | L | 27 | 31 |
| Sep. 26 | at | Utah (10-3) | L | 14 | 30 |
| Oct. 2 | vs | *Pittsburgh (10-3) | L | 10 | 35 |
| Oct. 10 | vs | Southern Mississippi (7-6) | W | 25 | 23 |
| Oct. 17 | at | *Connecticut (8-5) | L | 25 | 38 |
| Oct. 24 | at | *Cincinnati (12-1) | L | 10 | 41 |
| Oct. 31 | vs | Arkansas State (4-8) | W | 21 | 13 |
| Nov. 7 | at | *West Virginia (9-4) | L | 9 | 17 |
| Nov. 14 | vs | *Syracuse (4-8) | W | 10 | 9 |
| Nov. 21 | at | *South Florida (8-5) | L | 22 | 34 |
| Nov. 27 | vs | *Rutgers (9-4) | L | 14 | 34 |
| | 4-8-0 | | 217 | 315 |
| 2008-Louisville (Big East) |
| Aug. 31 | vs | Kentucky (7-6) | L | 2 | 27 |
| Sep. 6 | vs | Tennessee Tech ( ) | W | 51 | 10 |
| Sep. 17 | vs | Kansas State (5-7) | W | 38 | 29 |
| Sep. 26 | vs | *Connecticut (8-5) | L | 21 | 26 |
| Oct. 10 | at | Memphis (6-7) | W | 35 | 28 |
| Oct. 18 | vs | Middle Tennessee State (5-7) | W | 42 | 23 |
| Oct. 25 | vs | *South Florida (8-5) | W | 24 | 20 |
| Nov. 1 | at | *Syracuse (3-9) | L | 21 | 28 |
| Nov. 8 | at | *Pittsburgh (9-4) | L | 7 | 41 |
| Nov. 14 | vs | *Cincinnati (11-3) | L | 20 | 28 |
| Nov. 22 | vs | *West Virginia (9-4) | L | 21 | 35 |
| Dec. 4 | at | *Rutgers (8-5) | L | 14 | 63 |
| | 5-7-0 | | 296 | 358 |
| 2007-Louisville (Big East) |
| Aug. 30 | vs | Murray State ( ) | W | 73 | 10 |
| Sep. 6 | vs | Middle Tennessee State (5-7) | W | 58 | 42 |
| Sep. 15 | at | Kentucky (8-5) | L | 34 | 40 |
| Sep. 22 | vs | *Syracuse (2-10) | L | 35 | 38 |
| Sep. 29 | at | North Carolina State (5-7) | W | 29 | 10 |
| Oct. 5 | vs | Utah (9-4) | L | 35 | 44 |
| Oct. 13 | at | *Cincinnati (10-3) | W | 28 | 24 |
| Oct. 19 | at | *Connecticut (9-4) | L | 17 | 21 |
| Oct. 27 | vs | *Pittsburgh (5-7) | W | 24 | 17 |
| Nov. 8 | at | *West Virginia (11-2) | L | 31 | 38 |
| Nov. 17 | at | *South Florida (9-4) | L | 17 | 55 |
| Nov. 29 | vs | *Rutgers (8-5) | W | 41 | 38 |
| | 6-6-0 | | 422 | 377 |
| 2006-Louisville (Big East) |
| Sep. 3 | vs | Kentucky (8-5) | W | 59 | 28 |
| Sep. 9 | at | Temple (1-11) | W | 62 | 0 |
| Sep. 16 | vs | Miami (Florida) (7-6) | W | 31 | 7 |
| Sep. 23 | at | Kansas State (7-6) | W | 24 | 6 |
| Oct. 6 | vs | Middle Tennessee State (7-6) | W | 44 | 17 | at Nashville, TN |
| Oct. 14 | vs | *Cincinnati (8-5) | W | 23 | 17 |
| Oct. 21 | at | *Syracuse (4-8) | W | 28 | 13 |
| Nov. 2 | vs | *West Virginia (11-2) | W | 44 | 34 |
| Nov. 9 | at | *Rutgers (11-2) | L | 25 | 28 |
| Nov. 18 | vs | *South Florida (9-4) | W | 31 | 8 |
| Nov. 25 | at | *Pittsburgh (6-6) | W | 48 | 24 |
| Dec. 2 | vs | *Connecticut (4-8) | W | 48 | 17 |
| Jan. 2 | vs | Wake Forest (11-3) | W | 24 | 13 | at Miami, FL | Orange Bowl |
| | 12-1-0 | | 491 | 212 |
| 2005-Louisville (Big East) |
| Sep. 4 | at | Kentucky (3-8) | W | 31 | 24 |
| Sep. 17 | vs | Oregon State (5-6) | W | 63 | 27 |
| Sep. 24 | at | *South Florida (6-6) | L | 14 | 45 |
| Oct. 1 | vs | Florida Atlantic (2-9) | W | 61 | 10 |
| Oct. 8 | vs | North Carolina (5-6) | W | 69 | 14 |
| Oct. 15 | at | *West Virginia (11-1) | L | 44 | 46 |
| Oct. 22 | at | *Cincinnati (4-7) | W | 46 | 22 |
| Nov. 3 | vs | *Pittsburgh (5-6) | W | 42 | 20 |
| Nov. 11 | vs | *Rutgers (7-5) | W | 56 | 5 |
| Nov. 26 | vs | *Syracuse (1-10) | W | 41 | 17 |
| Dec. 3 | at | *Connecticut (5-6) | W | 30 | 20 |
| Jan. 2 | vs | Virginia Tech (11-2) | L | 24 | 35 | at Jacksonville, FL | Gator Bowl |
| | 9-3-0 | | 521 | 285 |
| 2004-Louisville (CUSA) |
| Sep. 5 | vs | Kentucky (2-9) | W | 28 | 0 |
| Sep. 11 | at | *Army (2-9) | W | 52 | 21 |
| Sep. 25 | at | North Carolina (6-6) | W | 34 | 0 |
| Oct. 2 | vs | *East Carolina (2-9) | W | 59 | 7 |
| Oct. 14 | at | Miami (Florida) (9-3) | L | 38 | 41 |
| Oct. 22 | vs | *South Florida (4-7) | W | 41 | 9 |
| Nov. 4 | at | *Memphis (8-4) | W | 56 | 49 |
| Nov. 10 | vs | *Texas Christian (5-6) | W | 55 | 28 |
| Nov. 20 | at | *Houston (3-8) | W | 65 | 27 |
| Nov. 27 | vs | *Cincinnati (7-5) | W | 70 | 7 |
| Dec. 4 | at | *Tulane (5-6) | W | 55 | 7 |
| Dec. 31 | vs | Boise State (11-1) | W | 44 | 40 | at Memphis, TN | Liberty Bowl |
| | 11-1-0 | | 597 | 236 |
| 2003-Louisville (CUSA) |
| Aug. 31 | at | Kentucky (4-8) | W | 40 | 24 |
| Sep. 13 | at | Syracuse (6-6) | W | 30 | 20 |
| Sep. 20 | vs | Texas-El Paso (2-11) | W | 42 | 14 |
| Sep. 27 | vs | Temple (1-11) | W | 21 | 12 |
| Oct. 4 | at | *South Florida (7-4) | L | 28 | 31 |
| Oct. 11 | vs | *Army (0-13) | W | 34 | 10 |
| Oct. 17 | vs | *Tulane (5-7) | W | 47 | 28 |
| Oct. 25 | at | *East Carolina (1-11) | W | 36 | 20 |
| Nov. 5 | at | *Texas Christian (11-2) | L | 28 | 31 |
| Nov. 15 | vs | *Memphis (9-4) | L | 7 | 37 |
| Nov. 22 | vs | *Houston (7-6) | W | 66 | 45 |
| Nov. 28 | at | *Cincinnati (5-7) | W | 43 | 40 |
| Dec. 18 | vs | Miami (Ohio) (13-1) | L | 28 | 49 | at Mobile, AL | GMAC Bowl |
| | 9-4-0 | | 450 | 361 |
| 2002-Louisville (CUSA) |
| Sep. 1 | vs | Kentucky (7-5) | L | 17 | 22 |
| Sep. 7 | at | Duke (2-10) | W | 40 | 3 |
| Sep. 14 | at | Colorado State (10-4) | L | 33 | 36 |
| Sep. 21 | at | *Army (1-11) | W | 45 | 14 |
| Sep. 26 | vs | Florida State (9-5) | W | 26 | 20 |
| Oct. 8 | at | *Memphis (3-9) | W | 38 | 32 |
| Oct. 19 | vs | *Texas Christian (10-2) | L | 31 | 45 |
| Oct. 26 | vs | *East Carolina (4-8) | W | 44 | 20 |
| Nov. 7 | vs | *Cincinnati (7-7) | L | 14 | 24 |
| Nov. 14 | at | *Southern Mississippi (7-6) | W | 20 | 17 |
| Nov. 23 | vs | *Alabama-Birmingham (5-7) | W | 41 | 21 |
| Nov. 30 | at | *Houston (5-7) | L | 10 | 27 |
| Dec. 18 | vs | Marshall (11-2) | L | 15 | 38 | at Mobile, AL | GMAC Bowl |
| | 7-6-0 | | 374 | 319 |
| 2001-Louisville (CUSA) |
| Aug. 23 | vs | New Mexico State (5-7) | W | 45 | 24 | at Louisville, KY | John Thompson Classic |
| Sep. 1 | at | Kentucky (2-9) | W | 36 | 10 |
| Sep. 8 | vs | Western Carolina ( ) | W | 31 | 7 |
| Sep. 22 | at | Illinois (10-2) | L | 10 | 34 |
| Sep. 29 | vs | *Memphis (5-6) | W | 38 | 21 |
| Oct. 4 | vs | Colorado State (7-5) | W | 7 | 2 |
| Oct. 16 | vs | *Southern Mississippi (6-5) | W | 24 | 14 |
| Oct. 27 | at | *Cincinnati (7-5) | W | 28 | 13 |
| Nov. 3 | at | *Tulane (3-9) | W | 52 | 7 |
| Nov. 10 | vs | *Houston (0-11) | W | 34 | 10 |
| Nov. 15 | at | *East Carolina (6-6) | W | 39 | 34 |
| Nov. 23 | at | *Texas Christian (6-6) | L | 22 | 37 |
| Dec. 31 | vs | Brigham Young (12-2) | W | 28 | 10 | at Memphis, TN | Liberty Bowl |
| | 11-2-0 | | 394 | 223 |
| 2000-Louisville (CUSA) |
| Sep. 2 | vs | Kentucky (2-9) | W | 40 | 34 |
| Sep. 9 | vs | Grambling State ( ) | W | 52 | 0 |
| Sep. 23 | at | Florida State (11-2) | L | 0 | 31 |
| Sep. 30 | vs | Connecticut (3-8) | W | 41 | 22 |
| Oct. 7 | at | *Alabama-Birmingham (7-4) | W | 38 | 17 |
| Oct. 14 | vs | *Cincinnati (7-5) | W | 38 | 24 |
| Oct. 19 | vs | *East Carolina (8-4) | L | 25 | 28 |
| Oct. 28 | vs | *Tulane (6-5) | W | 35 | 32 |
| Nov. 4 | at | *Southern Mississippi (8-4) | W | 49 | 28 |
| Nov. 11 | vs | *Army (1-10) | W | 38 | 17 |
| Nov. 18 | at | *Houston (3-8) | W | 32 | 13 |
| Dec. 29 | vs | Colorado State (10-2) | L | 17 | 22 | at Memphis, TN | Liberty Bowl |
| | 9-3-0 | | 405 | 268 |
| 1999-Louisville (CUSA) |
| Sep. 4 | at | Kentucky (6-6) | W | 56 | 28 |
| Sep. 11 | vs | Tennessee-Chattanooga ( ) | W | 58 | 30 |
| Sep. 18 | vs | Illinois (8-4) | L | 36 | 41 |
| Sep. 25 | vs | Oklahoma (7-5) | L | 21 | 42 |
| Oct. 2 | vs | Eastern Michigan (4-7) | W | 45 | 10 |
| Oct. 7 | at | *Army (3-8) | L | 52 | 59 |
| Oct. 16 | at | *Memphis (5-6) | W | 32 | 31 |
| Oct. 23 | vs | *Houston (7-4) | W | 39 | 33 |
| Oct. 30 | vs | *Alabama-Birmingham (5-6) | W | 23 | 14 |
| Nov. 6 | at | *Cincinnati (3-8) | W | 23 | 13 |
| Nov. 20 | vs | *Southern Mississippi (9-3) | L | 27 | 30 |
| Dec. 30 | vs | Boise State (10-3) | L | 31 | 34 | at Boise, ID | Humanitarian Bowl |
| | 7-5-0 | | 443 | 365 |
| 1998-Louisville (CUSA) |
| Sep. 5 | vs | Kentucky (7-5) | L | 34 | 68 |
| Sep. 12 | at | Utah (7-4) | L | 22 | 45 |
| Sep. 19 | at | Illinois (3-8) | W | 35 | 9 |
| Sep. 26 | vs | Boston College (4-7) | W | 52 | 28 |
| Oct. 3 | vs | *Cincinnati (2-9) | W | 62 | 19 |
| Oct. 10 | at | *Southern Mississippi (7-5) | L | 21 | 56 |
| Oct. 17 | at | *Tulane (12-0) | L | 22 | 28 |
| Oct. 24 | vs | *Memphis (2-9) | W | 35 | 32 |
| Oct. 31 | vs | Western Kentucky ( ) | W | 63 | 34 |
| Nov. 14 | at | *East Carolina (6-5) | W | 63 | 45 |
| Nov. 21 | vs | *Army (3-8) | W | 35 | 23 |
| Dec. 23 | vs | Marshall (12-1) | L | 29 | 48 | at Pontiac, MI | Motor City Bowl |
| | 7-5-0 | | 473 | 435 |
| 1997-Louisville (CUSA) |
| Aug. 30 | at | Kentucky (5-6) | L | 24 | 38 |
| Sep. 6 | vs | Utah (6-5) | L | 21 | 27 |
| Sep. 13 | vs | Illinois (0-11) | W | 26 | 14 |
| Sep. 20 | vs | Penn State (9-3) | L | 21 | 57 |
| Sep. 27 | at | Oklahoma (4-8) | L | 14 | 35 |
| Oct. 4 | at | *Southern Mississippi (9-3) | L | 24 | 42 |
| Oct. 11 | vs | *Tulane (7-4) | L | 33 | 64 |
| Oct. 25 | vs | *Houston (3-8) | L | 22 | 36 |
| Nov. 1 | vs | *East Carolina (5-6) | L | 31 | 45 |
| Nov. 8 | at | *Cincinnati (8-4) | L | 9 | 28 |
| Nov. 15 | at | *Memphis (4-7) | L | 20 | 21 |
| | 1-10-0 | | 245 | 407 |
| 1996-Louisville (CUSA) |
| Aug. 31 | at | Kentucky (4-7) | W | 38 | 14 |
| Sep. 7 | at | Penn State (11-2) | L | 7 | 24 |
| Sep. 14 | vs | Baylor (4-7) | L | 13 | 14 |
| Sep. 21 | at | Michigan State (6-6) | W | 30 | 20 |
| Sep. 28 | vs | *Southern Mississippi (8-3) | L | 7 | 24 |
| Oct. 12 | at | *Tulane (2-9) | W | 23 | 20 |
| Oct. 19 | vs | Northern Illinois (1-10) | W | 27 | 3 |
| Oct. 26 | vs | *Cincinnati (6-5) | L | 7 | 10 |
| Nov. 2 | vs | *Memphis (4-7) | W | 13 | 10 |
| Nov. 9 | at | North Carolina (10-2) | L | 10 | 28 |
| Nov. 16 | at | *Houston (7-5) | L | 7 | 38 |
| | 5-6-0 | | 182 | 205 |
| 1995-Louisville (Independent) |
| Sep. 2 | at | Kentucky (4-7) | W | 13 | 10 |
| Sep. 9 | at | Northern Illinois (3-8) | W | 34 | 21 |
| Sep. 16 | vs | Michigan State (6-5-1) | L | 7 | 30 |
| Sep. 21 | vs | North Carolina (7-5) | L | 10 | 17 |
| Sep. 30 | at | Memphis (3-8) | W | 17 | 7 |
| Oct. 7 | at | Southern Mississippi (6-5) | L | 21 | 25 |
| Oct. 14 | at | Wyoming (6-5) | L | 20 | 27 |
| Oct. 28 | vs | Maryland (6-5) | W | 31 | 0 |
| Nov. 4 | vs | Tulane (2-9) | W | 34 | 14 |
| Nov. 11 | vs | Louisiana-Monroe (2-9) | W | 39 | 0 |
| Nov. 18 | vs | North Texas (2-9) | W | 57 | 14 |
| | 7-4-0 | | 283 | 165 |
| 1994-Louisville (Independent) |
| Sep. 3 | at | Kentucky (1-10) | L | 14 | 20 |
| Sep. 10 | at | Texas (8-4) | L | 16 | 30 |
| Sep. 17 | at | Arizona State (3-8) | W | 25 | 22 |
| Oct. 1 | vs | Pittsburgh (3-8) | W | 33 | 29 |
| Oct. 8 | vs | North Carolina State (9-3) | W | 35 | 14 |
| Oct. 15 | at | Army (4-7) | L | 29 | 30 |
| Oct. 22 | at | Navy (3-8) | W | 35 | 14 |
| Oct. 29 | vs | Memphis (6-5) | W | 10 | 6 |
| Nov. 3 | vs | Boston College (7-4-1) | L | 14 | 35 |
| Nov. 12 | vs | Texas A&M (10-0-1) | L | 10 | 26 |
| Nov. 26 | vs | Tulsa (3-8) | W | 34 | 27 |
| | 6-5-0 | | 255 | 253 |
| 1993-Louisville (Independent) |
| Sep. 4 | vs | San Jose State (2-9) | W | 31 | 24 |
| Sep. 11 | at | Memphis (6-5) | W | 54 | 28 |
| Sep. 18 | vs | Arizona State (6-5) | W | 35 | 17 |
| Sep. 25 | vs | Texas (5-5-1) | W | 41 | 10 |
| Oct. 2 | at | Pittsburgh (3-8) | W | 29 | 7 |
| Oct. 9 | at | West Virginia (11-1) | L | 34 | 36 |
| Oct. 16 | vs | Southern Mississippi (2-8-1) | W | 35 | 27 |
| Oct. 23 | vs | Navy (4-7) | W | 28 | 0 |
| Nov. 6 | at | Tennessee (9-2-1) | L | 10 | 45 |
| Nov. 13 | at | Texas A&M (10-2) | L | 7 | 42 |
| Nov. 25 | at | Tulsa (4-6-1) | W | 28 | 0 |
| Dec. 28 | vs | Michigan State (6-6) | W | 18 | 7 | at Memphis, TN | Liberty Bowl |
| | 9-3-0 | | 350 | 243 |
| 1992-Louisville (Independent) |
| Sep. 5 | at | Ohio State (8-3-1) | L | 19 | 20 |
| Sep. 12 | vs | Memphis (6-5) | W | 16 | 15 |
| Sep. 19 | at | Arizona State (6-5) | L | 0 | 19 |
| Sep. 26 | vs | Wyoming (5-7) | L | 24 | 26 |
| Oct. 3 | vs | Syracuse (10-2) | L | 9 | 15 |
| Oct. 10 | vs | Virginia Tech (2-8-1) | W | 21 | 17 |
| Oct. 17 | vs | Tulsa (4-7) | W | 32 | 27 |
| Oct. 24 | at | Florida (9-4) | L | 17 | 31 |
| Oct. 31 | at | Cincinnati (3-8) | W | 27 | 17 |
| Nov. 7 | at | Texas A&M (12-1) | L | 18 | 40 |
| Nov. 14 | at | Pittsburgh (3-9) | W | 31 | 16 |
| | 5-6-0 | | 214 | 243 |
| 1991-Louisville (Independent) |
| Aug. 31 | vs | Eastern Kentucky ( ) | W | 24 | 14 |
| Sep. 5 | vs | Tennessee (9-3) | L | 11 | 28 |
| Sep. 14 | at | Ohio State (8-4) | L | 15 | 23 |
| Sep. 28 | vs | Southern Mississippi (4-7) | W | 28 | 14 |
| Oct. 5 | vs | Cincinnati (4-7) | L | 7 | 30 |
| Oct. 12 | at | Boston College (4-7) | L | 3 | 33 |
| Oct. 19 | vs | Army (4-7) | L | 12 | 37 |
| Oct. 26 | at | Virginia Tech (5-6) | L | 13 | 41 |
| Nov. 2 | vs | Florida State (11-2) | L | 15 | 40 |
| Nov. 9 | at | Memphis (5-6) | L | 7 | 35 |
| Nov. 16 | at | Tulsa (10-2) | L | 0 | 40 |
| | 2-9-0 | | 135 | 335 |
| 1990-Louisville (Independent) |
| Sep. 1 | at | San Jose State (9-2-1) | T | 10 | 10 |
| Sep. 8 | vs | Murray State ( ) | W | 68 | 0 |
| Sep. 15 | vs | Kansas (3-7-1) | W | 28 | 16 |
| Sep. 22 | at | West Virginia (4-7) | W | 9 | 7 |
| Sep. 29 | at | Southern Mississippi (8-4) | L | 13 | 25 |
| Oct. 6 | vs | Tulsa (3-8) | W | 38 | 14 |
| Oct. 13 | vs | Memphis (4-6-1) | W | 19 | 17 |
| Oct. 20 | at | Pittsburgh (3-7-1) | W | 27 | 20 |
| Oct. 27 | vs | Western Kentucky ( ) | W | 41 | 7 |
| Nov. 3 | vs | Cincinnati (1-10) | W | 41 | 16 | at Cincinnati, OH |
| Nov. 10 | vs | Boston College (4-7) | W | 17 | 10 |
| Jan. 1 | vs | Alabama (7-5) | W | 34 | 7 | at Tempe, AZ | Fiesta Bowl |
| | 10-1-1 | | 345 | 149 |
| 1989-Louisville (Independent) |
| Sep. 2 | at | Wyoming (5-6) | W | 28 | 21 |
| Sep. 9 | at | Kansas (4-7) | W | 33 | 28 |
| Sep. 23 | vs | West Virginia (8-3-1) | L | 21 | 30 |
| Sep. 30 | vs | Cincinnati (1-9-1) | W | 37 | 17 |
| Oct. 14 | vs | Southern Mississippi (5-6) | L | 10 | 16 |
| Oct. 21 | at | Tulsa (6-6) | L | 24 | 31 |
| Oct. 28 | at | Virginia (10-3) | L | 15 | 16 |
| Nov. 4 | vs | Western Kentucky ( ) | W | 55 | 7 |
| Nov. 11 | at | Memphis (2-9) | W | 40 | 10 |
| Nov. 18 | at | Boston College (2-9) | W | 36 | 22 |
| Dec. 4 | vs | Syracuse (8-4) | L | 13 | 24 | at Tokyo, Japan | Coca-Cola Classic |
| | 6-5-0 | | 312 | 222 |
| 1988-Louisville (Independent) |
| Sep. 3 | at | Maryland (5-6) | L | 16 | 27 |
| Sep. 8 | vs | Wyoming (11-2) | L | 9 | 44 |
| Sep. 17 | vs | Memphis (6-5) | W | 29 | 18 |
| Sep. 24 | at | North Carolina (1-10) | W | 38 | 34 |
| Oct. 1 | at | Southern Mississippi (10-2) | L | 23 | 30 |
| Oct. 8 | vs | Tulsa (4-7) | W | 9 | 3 |
| Oct. 15 | vs | Virginia (7-4) | W | 30 | 28 |
| Oct. 22 | at | Tulane (5-6) | W | 38 | 35 |
| Oct. 29 | at | Cincinnati (3-8) | W | 21 | 6 |
| Nov. 5 | vs | Virginia Tech (3-8) | W | 13 | 3 |
| Nov. 12 | vs | Western Kentucky ( ) | W | 35 | 17 |
| | 8-3-0 | | 261 | 245 |
| 1987-Louisville (Independent) |
| Sep. 5 | vs | Tulane (6-6) | W | 42 | 40 |
| Sep. 12 | vs | Cincinnati (4-7) | L | 0 | 25 |
| Sep. 19 | at | Purdue (3-7-1) | T | 22 | 22 |
| Sep. 26 | vs | Murray State ( ) | W | 34 | 10 |
| Oct. 3 | vs | Southern Mississippi (6-5) | L | 6 | 65 |
| Oct. 10 | vs | Marshall ( ) | L | 31 | 34 |
| Oct. 17 | at | Florida State (11-1) | L | 9 | 32 |
| Oct. 24 | vs | Akron (4-7) | W | 31 | 10 |
| Oct. 31 | at | Tulsa (3-8) | L | 22 | 26 |
| Nov. 7 | at | Tennessee (10-2-1) | L | 10 | 41 |
| Nov. 14 | at | Memphis (5-5-1) | L | 8 | 43 |
| | 3-7-1 | | 215 | 348 |
| 1986-Louisville (Independent) |
| Sep. 6 | at | Illinois (4-7) | L | 0 | 23 |
| Sep. 13 | at | Indiana (6-6) | L | 0 | 21 |
| Sep. 20 | vs | Western Kentucky ( ) | W | 45 | 6 |
| Sep. 27 | vs | Memphis (1-10) | W | 34 | 8 |
| Oct. 4 | at | Cincinnati (5-6) | L | 17 | 24 |
| Oct. 18 | at | Boston College (9-3) | L | 7 | 41 |
| Oct. 25 | vs | Florida State (7-4-1) | L | 18 | 54 |
| Nov. 1 | vs | Rutgers (5-5-1) | L | 0 | 41 |
| Nov. 8 | at | Tulane (4-7) | W | 23 | 12 |
| Nov. 15 | vs | West Virginia (4-7) | L | 19 | 42 |
| Nov. 22 | at | Southern Mississippi (6-5) | L | 16 | 31 |
| | 3-8-0 | | 179 | 303 |
| 1985-Louisville (Independent) |
| Sep. 7 | at | West Virginia (7-3-1) | L | 13 | 52 |
| Sep. 14 | at | Indiana (4-7) | L | 28 | 41 |
| Sep. 21 | vs | Western Kentucky ( ) | W | 23 | 14 |
| Sep. 28 | vs | Houston (4-7) | L | 27 | 49 |
| Oct. 5 | at | Syracuse (7-5) | L | 0 | 48 |
| Oct. 12 | vs | Southern Mississippi (7-4) | L | 12 | 42 |
| Oct. 19 | vs | Cincinnati (5-6) | L | 9 | 31 |
| Oct. 26 | at | Miami (Florida) (10-2) | L | 7 | 45 |
| Nov. 2 | vs | Central Florida ( ) | W | 42 | 21 |
| Nov. 9 | at | Virginia Tech (6-5) | L | 17 | 41 |
| Nov. 16 | vs | Eastern Kentucky ( ) | L | 21 | 45 |
| | 2-9-0 | | 199 | 429 |
| 1984-Louisville (Independent) |
| Sep. 1 | vs | Murray State ( ) | L | 23 | 26 |
| Sep. 8 | at | West Virginia (8-4) | L | 6 | 30 |
| Sep. 15 | vs | Southern Methodist (10-2) | L | 7 | 41 |
| Sep. 29 | at | Houston (7-5) | W | 30 | 28 |
| Oct. 6 | vs | Western Kentucky ( ) | W | 45 | 17 |
| Oct. 13 | vs | Indiana State (9-3) | L | 21 | 44 |
| Oct. 20 | at | Rutgers (7-3) | L | 21 | 38 |
| Oct. 27 | vs | Cincinnati (2-9) | L | 21 | 40 | at Cincinnati, OH |
| Nov. 3 | vs | Miami (Florida) (8-5) | L | 23 | 38 |
| Nov. 10 | vs | Tennessee State ( ) | L | 15 | 24 |
| Nov. 17 | at | Southern Mississippi (4-7) | L | 25 | 34 |
| | 2-9-0 | | 237 | 360 |
| 1983-Louisville (Independent) |
| Sep. 3 | at | Southern Methodist (10-2) | L | 6 | 24 |
| Sep. 10 | vs | Western Kentucky ( ) | W | 41 | 22 |
| Sep. 17 | vs | Army (2-9) | W | 31 | 7 |
| Sep. 24 | vs | Cincinnati (4-6-1) | W | 31 | 23 |
| Oct. 1 | at | Virginia Tech (9-2) | L | 0 | 31 |
| Oct. 8 | at | Miami (Florida) (11-1) | L | 14 | 42 |
| Oct. 15 | vs | Pittsburgh (8-3-1) | L | 10 | 55 |
| Oct. 20 | at | Florida State (7-5) | L | 7 | 51 |
| Nov. 5 | vs | Southern Mississippi (7-4) | L | 3 | 27 |
| Nov. 12 | at | Temple (4-7) | L | 7 | 24 |
| Nov. 24 | vs | Memphis (6-4-1) | L | 7 | 45 |
| | 3-8-0 | | 157 | 351 |
| 1982-Louisville (Independent) |
| Sep. 4 | vs | Western Kentucky ( ) | W | 20 | 10 |
| Sep. 11 | vs | Cincinnati (6-5) | L | 16 | 38 | at Cincinnati, OH |
| Sep. 25 | vs | Oklahoma State (4-5-2) | W | 28 | 22 |
| Oct. 2 | vs | Miami (Florida) (7-4) | L | 6 | 28 |
| Oct. 9 | vs | Temple (4-7) | L | 14 | 55 |
| Oct. 16 | vs | Richmond (0-10) | W | 35 | 0 |
| Oct. 23 | at | Southern Mississippi (7-4) | L | 0 | 48 |
| Oct. 30 | at | Pittsburgh (9-3) | L | 14 | 63 |
| Nov. 6 | vs | Indiana State (5-6) | W | 35 | 23 |
| Nov. 13 | at | Florida State (9-3) | L | 14 | 49 |
| Nov. 20 | at | Memphis (1-10) | W | 38 | 19 |
| | 5-6-0 | | 220 | 355 |
| 1981-Louisville (Independent) |
| Sep. 5 | at | Florida State (6-5) | L | 0 | 17 |
| Sep. 12 | vs | Toledo (9-3) | W | 31 | 6 |
| Sep. 19 | vs | Long Beach State (2-8) | W | 35 | 13 |
| Sep. 26 | at | Missouri (8-4) | L | 3 | 34 |
| Oct. 3 | vs | Marshall (2-9) | W | 36 | 0 |
| Oct. 10 | at | Memphis (1-10) | W | 14 | 7 |
| Oct. 17 | vs | Tennessee State ( ) | L | 30 | 42 |
| Oct. 24 | at | Oklahoma State (7-5) | L | 11 | 19 |
| Nov. 7 | vs | Louisiana-Monroe (5-6) | L | 7 | 40 |
| Nov. 14 | at | Cincinnati (6-5) | L | 0 | 24 |
| Nov. 21 | vs | Southern Mississippi (9-2-1) | W | 13 | 10 |
| | 5-6-0 | | 180 | 212 |
| 1980-Louisville (Independent) |
| Sep. 6 | vs | Miami (Florida) (9-3) | L | 10 | 24 |
| Sep. 13 | at | Florida State (10-2) | L | 0 | 52 |
| Sep. 20 | vs | Murray State ( ) | L | 9 | 13 |
| Sep. 27 | at | Kansas (4-5-2) | W | 17 | 9 |
| Oct. 11 | vs | Memphis (2-9) | W | 38 | 14 |
| Oct. 18 | vs | Indiana State (6-5) | W | 27 | 17 |
| Oct. 25 | at | Florida (8-4) | L | 0 | 13 |
| Nov. 1 | vs | Temple (4-7) | L | 12 | 17 |
| Nov. 8 | at | Pittsburgh (11-1) | L | 23 | 41 |
| Nov. 15 | vs | Cincinnati (2-9) | W | 20 | 0 |
| Nov. 22 | at | Southern Mississippi (9-3) | W | 6 | 3 |
| | 5-6-0 | | 162 | 203 |
| 1979-Louisville (Independent) |
| Sep. 8 | vs | Virginia Tech (5-6) | L | 14 | 15 |
| Sep. 15 | at | Miami (Florida) (5-6) | L | 12 | 24 |
| Sep. 22 | vs | Cincinnati (2-9) | W | 22 | 19 |
| Sep. 29 | at | Drake (3-8) | W | 31 | 21 |
| Oct. 6 | vs | Florida State (11-1) | L | 0 | 27 |
| Oct. 13 | vs | Tulsa (6-5) | W | 24 | 7 |
| Oct. 20 | at | Indiana State (8-3) | W | 34 | 10 |
| Nov. 3 | vs | Southern Mississippi (6-4-1) | T | 10 | 10 |
| Nov. 10 | at | Memphis (5-6) | L | 6 | 10 |
| Nov. 17 | at | Maryland (7-4) | L | 7 | 28 |
| Nov. 25 | vs | Rutgers (8-3) | L | 7 | 31 |
| | 4-6-1 | | 167 | 202 |
| 1978-Louisville (Independent) |
| Sep. 9 | vs | South Dakota State ( ) | W | 54 | 7 |
| Sep. 16 | vs | Maryland (9-3) | L | 17 | 24 |
| Sep. 23 | at | Cincinnati (5-6) | W | 28 | 14 |
| Sep. 30 | vs | Indiana State (3-8) | W | 31 | 12 |
| Oct. 7 | at | Tulsa (9-2) | L | 7 | 24 |
| Oct. 14 | vs | Northwestern State (5-6) | W | 51 | 7 |
| Oct. 21 | vs | Boston University ( ) | W | 35 | 7 |
| Oct. 28 | vs | William & Mary (5-5-1) | W | 33 | 21 |
| Nov. 4 | at | Wichita State (4-7) | W | 38 | 20 |
| Nov. 11 | vs | Memphis (4-7) | L | 22 | 29 |
| Nov. 18 | at | Southern Mississippi (7-4) | L | 3 | 37 |
| | 7-4-0 | | 319 | 202 |
| 1977-Louisville (Independent) |
| Sep. 10 | vs | Northern Illinois (3-8) | W | 38 | 0 |
| Sep. 17 | vs | Cincinnati (5-4-2) | T | 17 | 17 |
| Sep. 24 | vs | William & Mary (6-5) | L | 7 | 21 |
| Oct. 1 | at | Memphis (6-5) | W | 14 | 13 |
| Oct. 8 | vs | Tulsa (3-8) | W | 33 | 0 |
| Oct. 15 | at | Dayton ( ) | L | 10 | 14 |
| Oct. 22 | at | Alabama (11-1) | L | 6 | 55 |
| Oct. 29 | at | Marshall (2-9) | W | 56 | 0 |
| Nov. 5 | vs | Wichita State (5-6) | W | 51 | 21 |
| Nov. 12 | vs | Drake (2-9) | W | 18 | 13 |
| Nov. 20 | vs | Indiana State (3-7) | W | 27 | 16 |
| Dec. 17 | vs | Louisiana Tech (9-1-2) | L | 14 | 24 | at Shreveport, LA | Independence Bowl |
| | 7-4-1 | | 291 | 194 |
| 1976-Louisville (Independent) |
| Sep. 18 | at | Mississippi State (9-2) | L | 21 | 30 |
| Sep. 25 | vs | Drake (1-10) | W | 37 | 24 |
| Oct. 2 | vs | Wichita State (4-7) | W | 28 | 14 |
| Oct. 9 | at | Pittsburgh (12-0) | L | 6 | 27 |
| Oct. 16 | vs | Louisiana-Monroe (2-9) | W | 36 | 8 |
| Oct. 23 | at | Alabama (9-3) | L | 3 | 24 |
| Oct. 30 | vs | Tulsa (7-4-1) | L | 10 | 20 |
| Nov. 6 | at | Rutgers (11-0) | L | 0 | 34 |
| Nov. 13 | vs | Memphis (7-4) | L | 14 | 26 |
| Nov. 20 | vs | Boston University ( ) | W | 16 | 7 |
| Nov. 27 | at | Cincinnati (8-3) | L | 6 | 20 |
| | 4-7-0 | | 177 | 234 |
| 1975-Louisville (Independent) |
| Sep. 13 | vs | Western Kentucky ( ) | L | 17 | 21 |
| Sep. 20 | at | Drake (3-8) | L | 7 | 31 |
| Sep. 27 | vs | Cincinnati (6-5) | L | 27 | 46 |
| Oct. 4 | at | Wichita State (3-8) | L | 10 | 13 |
| Oct. 11 | vs | Tennessee-Chattanooga (5-5-1) | W | 6 | 3 |
| Oct. 18 | at | Memphis (7-4) | L | 7 | 41 |
| Oct. 25 | vs | Mississippi State (6-4-1) | L | 14 | 28 |
| Nov. 1 | at | Tulsa (7-4) | L | 14 | 38 |
| Nov. 8 | vs | Dayton (5-6) | L | 13 | 32 |
| Nov. 15 | at | Louisiana-Monroe (4-6-1) | L | 10 | 14 |
| Nov. 22 | at | West Texas A&M (5-6) | L | 23 | 49 |
| | 1-10-0 | | 148 | 316 |
| 1974-Louisville (MVC) |
| Sep. 7 | vs | Memphis (7-4) | L | 10 | 16 |
| Sep. 14 | vs | Auburn (10-2) | L | 3 | 16 | at Birmingham, AL |
| Sep. 28 | at | Cincinnati (7-4) | L | 6 | 7 |
| Oct. 5 | at | *Wichita State (1-9-1) | W | 14 | 7 |
| Oct. 12 | at | *North Texas (2-7-2) | W | 24 | 10 |
| Oct. 19 | vs | *Drake (3-7-1) | L | 35 | 38 |
| Oct. 26 | at | Mississippi State (9-3) | L | 7 | 56 |
| Nov. 2 | vs | *Tulsa (8-3) | L | 7 | 37 |
| Nov. 9 | vs | Dayton (3-8) | W | 20 | 15 |
| Nov. 23 | vs | Vanderbilt (7-3-2) | L | 0 | 44 |
| Nov. 30 | vs | *West Texas A&M (6-5) | W | 10 | 8 |
| | 4-7-0 | | 136 | 254 |
| 1973-Louisville (MVC) |
| Sep. 8 | at | Memphis (8-3) | L | 21 | 28 |
| Sep. 15 | at | Kent State (9-2) | L | 3 | 10 |
| Sep. 22 | at | *Drake (2-9) | W | 27 | 17 |
| Oct. 6 | vs | *Wichita State (4-7) | W | 24 | 10 |
| Oct. 13 | at | *North Texas (5-5-1) | L | 6 | 7 |
| Oct. 20 | vs | Mississippi State (4-5-2) | L | 7 | 18 |
| Oct. 27 | vs | Cincinnati (4-7) | W | 10 | 8 |
| Nov. 3 | at | *Tulsa (6-5) | L | 9 | 17 |
| Nov. 10 | vs | Dayton (5-5-1) | L | 9 | 10 |
| Nov. 17 | vs | Furman (7-4) | W | 35 | 14 |
| Nov. 24 | at | *West Texas A&M (2-9) | W | 21 | 9 |
| | 5-6-0 | | 172 | 148 |
| 1972-Louisville (MVC) |
| Sep. 16 | vs | Kent State (6-5-1) | W | 34 | 0 |
| Sep. 30 | at | Dayton (4-6-1) | W | 28 | 11 |
| Oct. 7 | at | Tampa (10-2) | W | 17 | 14 |
| Oct. 14 | vs | *North Texas (1-10) | W | 56 | 6 |
| Oct. 21 | at | *Wichita State (6-5) | W | 46 | 3 |
| Oct. 28 | at | Cincinnati (2-9) | W | 38 | 13 |
| Nov. 4 | vs | *Tulsa (4-7) | L | 26 | 28 |
| Nov. 11 | at | Southern Illinois (1-8-1) | W | 20 | 16 |
| Nov. 18 | vs | *Memphis (5-5-1) | W | 17 | 0 |
| Nov. 25 | vs | *Drake (7-5) | W | 27 | 0 |
| | 9-1-0 | | 309 | 91 |
| 1971-Louisville (MVC) |
| Sep. 18 | at | Vanderbilt (4-6-1) | T | 0 | 0 |
| Sep. 25 | at | *Drake (7-4) | L | 7 | 10 |
| Oct. 2 | vs | Dayton (5-6) | W | 41 | 13 |
| Oct. 9 | at | *Memphis (5-6) | W | 26 | 20 |
| Oct. 16 | vs | *North Texas (3-8) | L | 17 | 20 | at Irving, TX |
| Oct. 23 | vs | *Wichita State (3-8) | W | 21 | 5 |
| Oct. 30 | vs | Tampa (6-5) | W | 21 | 10 |
| Nov. 6 | at | *Tulsa (4-7) | W | 17 | 0 |
| Nov. 13 | vs | Southern Illinois ( ) | W | 24 | 14 |
| Nov. 27 | vs | Cincinnati (7-4) | L | 16 | 19 |
| | 6-3-1 | | 190 | 111 |
| 1970-Louisville (MVC) |
| Sep. 12 | at | Florida State (7-4) | L | 7 | 9 |
| Sep. 19 | at | Southern Illinois ( ) | L | 28 | 31 |
| Sep. 26 | vs | *North Texas (3-8) | W | 13 | 2 |
| Oct. 3 | at | Dayton (5-4-1) | L | 11 | 28 |
| Oct. 10 | vs | *Tulsa (6-4) | W | 14 | 8 |
| Oct. 17 | at | Marshall (3-6) | W | 16 | 14 |
| Oct. 31 | vs | Kent State (3-7) | W | 14 | 13 |
| Nov. 7 | vs | *Memphis (6-4) | W | 40 | 27 |
| Nov. 14 | at | Cincinnati (7-4) | W | 28 | 14 |
| Nov. 21 | vs | Drake ( ) | W | 23 | 14 |
| Nov. 28 | at | *Wichita State (0-9) | W | 34 | 24 |
| Dec. 19 | vs | Long Beach State (9-2-1) | T | 24 | 24 | at Pasadena, CA | Pasadena Bowl |
| | 8-3-1 | | 252 | 208 |
| 1969-Louisville (MVC) |
| Sep. 13 | at | Drake ( ) | T | 24 | 24 |
| Sep. 20 | vs | Southern Illinois ( ) | W | 17 | 13 |
| Oct. 4 | vs | Dayton (3-7) | W | 24 | 17 |
| Oct. 18 | vs | Marshall (3-7) | W | 34 | 17 |
| Oct. 25 | at | *North Texas (7-3) | L | 13 | 31 |
| Nov. 1 | at | Kent State (5-5) | L | 6 | 35 |
| Nov. 8 | vs | *Cincinnati (4-6) | L | 21 | 31 |
| Nov. 15 | vs | *Wichita State (2-8) | W | 13 | 7 |
| Nov. 22 | at | *Memphis (8-2) | L | 19 | 69 |
| Nov. 27 | at | *Tulsa (1-9) | W | 35 | 29 |
| | 5-4-1 | | 206 | 273 |
| 1968-Louisville (MVC) |
| Sep. 21 | at | Southern Illinois ( ) | W | 33 | 10 |
| Oct. 5 | at | Dayton (5-5) | L | 14 | 28 |
| Oct. 12 | vs | *Tulsa (3-7) | W | 16 | 7 |
| Oct. 19 | at | Marshall (0-9-1) | W | 13 | 10 |
| Oct. 26 | at | *Wichita State (0-10) | W | 21 | 14 |
| Nov. 2 | vs | Kent State (1-9) | W | 23 | 9 |
| Nov. 9 | at | *Cincinnati (5-4-1) | L | 7 | 37 |
| Nov. 16 | vs | *North Texas (8-2) | L | 14 | 36 |
| Nov. 23 | vs | Drake ( ) | L | 37 | 38 |
| Nov. 30 | vs | *Memphis (6-4) | L | 14 | 44 |
| | 5-5-0 | | 192 | 233 |
| 1967-Louisville (MVC) |
| Sep. 16 | at | Drake ( ) | W | 46 | 7 |
| Sep. 23 | vs | Southern Illinois ( ) | W | 26 | 0 |
| Sep. 30 | at | *North Texas (7-1-1) | L | 28 | 30 |
| Oct. 7 | vs | Dayton (6-3-1) | W | 29 | 7 |
| Oct. 14 | at | East Carolina (8-2) | L | 13 | 18 |
| Oct. 21 | vs | Marshall (0-10) | W | 43 | 7 |
| Oct. 28 | vs | *Wichita State (2-7-1) | W | 24 | 17 |
| Nov. 4 | at | Kent State (5-5) | L | 21 | 28 |
| Nov. 11 | vs | *Cincinnati (3-6) | L | 7 | 13 |
| Dec. 2 | at | *Tulsa (7-3) | L | 23 | 35 |
| | 5-5-0 | | 260 | 162 |
| 1966-Louisville (MVC) |
| Sep. 24 | at | Southern Illinois ( ) | W | 16 | 7 |
| Oct. 1 | vs | *North Texas (8-2) | L | 19 | 20 |
| Oct. 8 | at | Dayton (8-2) | L | 17 | 20 |
| Oct. 15 | vs | Drake ( ) | W | 66 | 26 |
| Oct. 22 | at | Marshall (2-8) | W | 35 | 15 |
| Oct. 29 | at | *Wichita State (2-8) | L | 2 | 9 |
| Nov. 5 | vs | Kent State (4-6) | W | 23 | 20 |
| Nov. 12 | at | *Cincinnati (3-7) | L | 3 | 17 |
| Nov. 19 | vs | *Tulsa (6-4) | W | 29 | 18 |
| Nov. 26 | vs | East Carolina (4-5-1) | W | 21 | 7 |
| | 6-4-0 | | 231 | 159 |
| 1965-Louisville (MVC) |
| Sep. 18 | at | Western Michigan (6-2-1) | L | 13 | 17 |
| Sep. 25 | vs | Southern Illinois ( ) | W | 13 | 0 |
| Oct. 2 | at | *North Texas (3-7) | W | 29 | 21 |
| Oct. 9 | vs | Dayton (1-8-1) | W | 34 | 0 |
| Oct. 16 | vs | East Carolina (9-1) | L | 20 | 34 |
| Oct. 23 | vs | Marshall (5-5) | W | 23 | 7 |
| Oct. 30 | vs | *Wichita State (2-7) | W | 30 | 10 |
| Nov. 6 | at | *Tulsa (8-3) | L | 18 | 51 |
| Nov. 13 | at | Drake ( ) | W | 32 | 17 |
| Nov. 20 | at | Kent State (5-4-1) | L | 6 | 7 |
| | 6-4-0 | | 218 | 164 |
| 1964-Louisville (MVC) |
| Sep. 19 | vs | Western Michigan (3-6) | L | 7 | 10 |
| Sep. 26 | at | Southern Illinois ( ) | L | 6 | 7 |
| Oct. 3 | vs | *North Texas (2-7-1) | L | 0 | 22 |
| Oct. 10 | at | Dayton (3-7) | W | 21 | 7 |
| Oct. 17 | vs | *Tulsa (9-2) | L | 0 | 58 |
| Oct. 24 | at | Marshall (7-3) | L | 6 | 28 |
| Oct. 31 | at | *Wichita State (4-6) | L | 15 | 23 |
| Nov. 7 | vs | Kent State (3-5-1) | L | 7 | 14 |
| Nov. 14 | at | Memphis (5-4) | L | 0 | 34 |
| Nov. 21 | vs | Drake ( ) | L | 8 | 14 |
| | 1-9-0 | | 70 | 217 |
| 1963-Louisville (MVC) |
| Sep. 28 | at | *North Texas (3-6) | L | 6 | 26 |
| Oct. 5 | vs | Southern Illinois ( ) | L | 7 | 13 |
| Oct. 12 | vs | Dayton (1-7-2) | W | 13 | 12 |
| Oct. 19 | vs | *Wichita State (7-2) | L | 14 | 47 |
| Oct. 26 | vs | Marshall (5-4-1) | W | 27 | 14 |
| Nov. 2 | vs | Memphis (9-0-1) | L | 0 | 25 |
| Nov. 9 | at | Kent State (3-5-1) | L | 7 | 26 |
| Nov. 16 | at | Western Michigan (2-7) | W | 21 | 7 |
| Dec. 7 | at | *Tulsa (5-5) | L | 16 | 22 |
| Dec. 14 | at | Houston (2-8) | L | 7 | 21 |
| | 3-7-0 | | 118 | 213 |
| 1962-Louisville (Independent) |
| Sep. 15 | at | Wichita State (3-7) | W | 21 | 20 |
| Sep. 22 | vs | Western Michigan (5-4) | W | 27 | 21 |
| Sep. 29 | at | Marshall (4-6) | W | 18 | 0 |
| Oct. 6 | at | Memphis (8-1) | L | 0 | 49 |
| Oct. 13 | at | Dayton (2-8) | W | 21 | 0 |
| Oct. 20 | at | Tulsa (5-5) | L | 7 | 25 |
| Nov. 3 | vs | Xavier (6-4) | L | 12 | 13 |
| Nov. 10 | vs | Kent State (3-6) | W | 29 | 8 |
| Nov. 17 | vs | North Texas (6-4) | W | 14 | 10 |
| Nov. 24 | vs | Houston (7-4) | L | 25 | 27 |
| | 6-4-0 | | 174 | 173 |
