"I just feel more comfortable out on the court and it just feels so right," the sophomore guard said.
After missing their first two shots, the Cardinals made nine of their next 14.
Meanwhile, the RedHawks missed their first nine shots and trailed 16-0 before LaTrese Saine made a pair of free throws at the 3:15 mark.
Ashton Luttrull hit a 3-pointer for Southeast Missouri State that made it 22-5, but the Cardinals closed the first half on a 14-0 run to lead 42-11.
Dana Evans and Kylee Shook each had 11 points and Bionca Dunham 10 off the bench for Louisville.
Tesia Thompson had 10 points for the Redhawks, who scored 15 points in the third quarter and 14 in the fourth.